In the present study, we report the efficient synthesis of a novel quinoline–chromene hybrid, 4- hydroxy-3-(3-(4-oxo-4H-chromen-3-yl)acryloyl)-1-phenylquinolin-2(1H)-one, utilizing a straightforward conventional strategy. The target compound was prepared via a piperidine-catalyzed Knoevenagel-type condensation of 3-acetyl-4-hydroxy-1-phenylquinolin-2(1H)-one with 4-oxo-4H- chromene-3-carbaldehyde in ethanol. Employing piperidine as a mild organic catalyst, this single-step approach avoids harsh reagents and provides the product in excellent yield, underscoring its practicality for routine laboratory synthesis. Reaction progress was monitored via thin-layer chromatography (TLC), and the structural framework of the purified hybrid architecture was comprehensively characterized using elemental analysis alongside 1H NMR, 13C NMR, FT-IR, and Mass spectrometry. Given the well-documented, diverse bioactivity profiles of both individual quinoline and chromene moieties, the successful synthesis of this novel hybrid scaffold holds significant promise for drug discovery. This study provides a foundational framework for ongoing investigations aimed at exploring the pharmacological properties and establishing the structure–activity relationships (SAR) of this versatile heterocycle