Anisomeles indica, a medicinal plant belonging to the Lamiaceae family, is widely distributed in tropical and subtropical regions and is known for its antimicrobial, antioxidant, anti-inflammatory, and insecticidal properties. The present study focuses on the extraction and characterization of essential oil from Anisomeles indica leaves and the development of nanoemulsion formulations to evaluate their insecticidal efficacy against selected insect pests. Essential oil extraction was carried out using hydrodistillation, while GC-MS analysis was employed to identify major phytochemical constituents. Nanoemulsions were prepared using suitable surfactants and optimized based on particle size, zeta potential, encapsulation efficiency, and stability parameters. The insecticidal activity of the formulations was assessed through contact toxicity and fumigation bioassays under controlled laboratory conditions. Repellency activity, mortality rate, and insect behavioral responses were statistically analyzed. The nanoemulsion formulations exhibited enhanced insecticidal activity compared to crude essential oil due to improved dispersion and penetration efficiency. The study highlights the potential application of eco-friendly, biodegradable, and sustainable plant-based nanoformulations for agricultural pest management and public health protection.