This study describes how strontium oxide (SrO₂) and zirconium-doped SrO₂ (Zr–SrO₂) nanoparticles were made using a low-temperature solution combustion method with tannic The study carefully examined the structure and shape of the materials created using different methods, such as X-ray diffraction (XRD), energy-dispersive X-ray analysis (EDAX), UV–Visible spectroscopy (UV–Vis), and XRD shows that only one kind of orthorhombic SrO₂ was formed, and when Zr was added, the peaks became wider and the structure changed, indicating that Zr was included. The analysis of crystallite size showed that it went from 21.7–31.1 nm (SrO₂) to 16.3–21.6 nm (Zr–SrO₂). This was because the dopant made the grains finer. Electrochemical tests with a Zr–SrO₂ electrode in a 2 M KOH solution showed that Zr–SrO₂ had much better redox activity and electrochemical Additionally, the Zr-doped sample showed a strong ability to specifically detect histidine, suggesting it could be useful for creating biosensors. These results underscore the effectiveness of Zr doping in modulating the physicochemical and electrochemical behaviour of SrO₂, making it a promising candidate for advanced electrochemical and biosensing applications.